ZURZUVAE can be used to treat many types of patients with postpartum depression (PPD)
Select each profile to see why ZURZUVAE® (zuranolone) may be appropriate for these patient types.
These are hypothetical profiles only. All treatment decisions should be up to the discretion of the HCP and patient,
as each patient’s situation may vary.
Actor portrayals.
-
Experiencing symptoms
for the first time -
Previously took an oral antidepressant; experiencing new symptoms
-
Experiencing symptoms
while
taking an oral
antidepressant
“I thought I just had the baby blues and it would get better, but the sadness I felt in the first few weeks didn’t go away”
Patient history and
screening
- No history of depression or antidepressant use
- OBGYN nurse practitioner screened for depressive symptoms with EPDS in the first trimester to establish baseline
Symptom presentation
- Down and disengaged days
before delivery - Felt overwhelmed and had brain fog immediately after delivery, and felt consistent sadness in the weeks after giving birth
PPD diagnosis and
treatment considerations
- Screening was suggestive of PPD at virtual visit 4 weeks postpartum
- At in-person follow-up, persistent and worsening symptoms noted and PPD diagnosis made
- Met DSM-5-TR criteria for PPD, presenting with depressed mood, loss of interest in activities, loss of energy, feelings of guilt, and difficulty concentrating
- Concerned about being on an antidepressant long-term
DSM-5-TR, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision; EPDS, Edinburgh Postnatal Depression Scale.
DSM-5-TR criteria
Diagnostic criteria for a major depressive episode with peripartum onset3
Patients must have 5 or more of the following symptoms nearly every day* during the same 2-week period and change from previous functioning. At least 1 symptom must either be depressed mood or loss of interest/pleasure.
- Depressed mood most of the day
- Loss of interest/pleasure in almost all activities most of the day
- Significant change in weight or appetite
- Insomnia or hypersomnia
- Psychomotor agitation/retardation
- Loss of energy or fatigue
- Feelings of worthlessness or excessive or inappropriate guilt
- Difficulty concentrating or indecisiveness
- Recurrent suicidal thoughts or actions or recurrent thoughts of death
Additional criteria:
- Symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
- Episode is not attributable to the physiological effects of a substance or to another medical condition
Peripartum onset specifier:
- Symptom onset occurs during pregnancy or within 4 weeks after delivery
*”Nearly every day” does not apply to weight gain and recurrent suicidal thoughts or actions or recurrent thoughts of death.
These are not the complete diagnostic criteria for PPD. The criteria listed here are adapted from the DSM-5-TR®. DSM-5® is a registered trademark of the American Psychiatric Association.
“I took an antidepressant in the past, but I stopped taking it.
I don’t want to try it again”
Patient history and
screening
- Took antidepressant previously; not currently on treatment
- OBGYN screened for depressive symptoms throughout pregnancy; on high alert for symptoms during the third trimester and after delivery
Symptom presentation
- Depressed, tired, and irritable
a few weeks after delivery - Worried about symptoms impacting her life
PPD diagnosis and
treatment considerations
- At 6-week appointment, admitted to “toughing it out” despite worsening symptoms
- OBGYN nurse practitioner assessed Ava and diagnosed her with PPD
- Met DSM-5-TR criteria for PPD, presenting with depressed mood, insomnia, psychomotor agitation, fatigue, feelings of worthlessness, and indecisiveness
- Hesitant about taking her prior antidepressant again
DSM-5-TR criteria
Diagnostic criteria for a major depressive episode with peripartum onset3
Patients must have 5 or more of the following symptoms nearly every day* during the same 2-week period and change from previous functioning. At least 1 symptom must either be depressed mood or loss of interest/pleasure.
- Depressed mood most of the day
- Loss of interest/pleasure in almost all activities most of the day
- Significant change in weight or appetite
- Insomnia or hypersomnia
- Psychomotor agitation/retardation
- Loss of energy or fatigue
- Feelings of worthlessness or excessive or inappropriate guilt
- Difficulty concentrating or indecisiveness
- Recurrent suicidal thoughts or actions or recurrent thoughts of death
Additional criteria:
- Symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
- Episode is not attributable to the physiological effects of a substance or to another medical condition
Peripartum onset specifier:
- Symptom onset occurs during pregnancy or within 4 weeks after delivery
*”Nearly every day” does not apply to weight gain and recurrent suicidal thoughts or actions or recurrent thoughts of death.
These are not the complete diagnostic criteria for PPD. The criteria listed here are adapted from the DSM-5-TR®. DSM-5® is a registered trademark of the American Psychiatric Association.
“I have no energy these days and I can’t seem to focus or make decisions.
I’m nervous to go back to work soon”
Patient history and
screening
- Prescribed antidepressant prior to pregnancy, which she continued throughout
- Screened for depressive symptoms throughout pregnancy
Symptom presentation
- New symptoms of depressed
mood and feeling worthless - Felt anxious about her ability to care for her newborn, which also impacted her sleep
- Worried about returning to work soon after new symptoms started several weeks ago
PPD diagnosis and
treatment considerations
- At 6-week appointment, OBGYN assessed Kiera and diagnosed her with PPD
- Met DSM-5-TR criteria for PPD, presenting with depressed mood, significant change in weight, insomnia, fatigue, feelings of worthlessness, and difficulty concentrating
- Discussed treatment options that could be used with her current antidepressant
DSM-5-TR criteria
Diagnostic criteria for a major depressive episode with peripartum onset3
Patients must have 5 or more of the following symptoms nearly every day* during the same 2-week period and change from previous functioning. At least 1 symptom must either be depressed mood or loss of interest/pleasure.
- Depressed mood most of the day
- Loss of interest/pleasure in almost all activities most of the day
- Significant change in weight or appetite
- Insomnia or hypersomnia
- Psychomotor agitation/retardation
- Loss of energy or fatigue
- Feelings of worthlessness or excessive or inappropriate guilt
- Difficulty concentrating or indecisiveness
- Recurrent suicidal thoughts or actions or recurrent thoughts of death
Additional criteria:
- Symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
- Episode is not attributable to the physiological effects of a substance or to another medical condition
Peripartum onset specifier:
- Symptom onset occurs during pregnancy or within 4 weeks after delivery
*”Nearly every day” does not apply to weight gain and recurrent suicidal thoughts or actions or recurrent thoughts of death.
These are not the complete diagnostic criteria for PPD. The criteria listed here are adapted from the DSM-5-TR®. DSM-5® is a registered trademark of the American Psychiatric Association.
